Water → 2-(2-Chlorophenyl)cyclopropanecarboxylic acid

HRID 857003

반응식

HRID 857003 반응식
CON(C)[C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:5].[OH2:17].[OH-].[Na+]>CO>[Cl:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH:7]1[CH2:8][CH:6]1[C:4]([OH:17])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 587594752-(2-Chlorophenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide

생성물 1

HCID 218646682-(2-Chlorophenyl)cyclopropanecarboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-(2-chloro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide (9.6 g), water (20 mL), and NaOH (3.2 g) in MeOH (40 mL) was refluxed for 3 h. The reaction mixture was cooled down to room temperature and concentrated in vacuo. The residue was acidified by 6 N HCl followed by extraction with CH2Cl2. The organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo to give the title compound (7.8 g).

후처리

  1. temperaturewas refluxed for 3 h
  2. concentrationconcentrated in vacuo
  3. extractionfollowed by extraction with CH2Cl2
  4. washThe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-98b7c5c04e7d4f3da71310343e4146fa
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144881B2

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