Water → 2-(2,5-Difluorophenyl)cyclopropane-1-carboxylic acid

HRID 857018노트

반응식

HRID 857018 반응식
CON(C)[C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[F:16])=[O:5].[OH2:18].[OH-].[Na+]>CO>[F:16][C:10]1[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=1[CH:7]1[CH2:8][CH:6]1[C:4]([OH:18])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 587594682-(2,5Difluoro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide

생성물 1

HCID 218646562-(2,5-Difluorophenyl)cyclopropane-1-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide (9.6 g), water (20 mL), and NaOH (3.2 g) in MeOH (40 mL) was refluxed for 3 h. The reaction mixture was cooled down to room temperature and concentrated in vacuo. The residue was acidified by 6 N HCl followed by extraction with CH2Cl2. The organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo to give the title compound (7.8 g).

후처리

  1. temperaturewas refluxed for 3 h
  2. concentrationconcentrated in vacuo
  3. extractionfollowed by extraction with CH2Cl2
  4. washThe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6641a8c6dfa44a82a822587065683740
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144881B2

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