Hydrochloric Acid → (R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

HRID 857026노트

반응식

HRID 857026 반응식
C(OC(=O)[NH:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10])(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH2:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57419701(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester

생성물 1

HCID 57462036(R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester (2.5 g) and 9 mL of 4 N HCl in ethyl acetate at 50° C. was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound (1.2 g) as a solid which was used in the next step without further purification.

후처리

  1. concentrationAfter concentration
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f388d190d9db4f81adbcdec40d8a0a90
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144881B2

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