8-(2-Benzothiazolyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(Benzothiazol-2-yl)-4-hydroxycyclohexan-1-one

HRID 857077

반응식

HRID 857077 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1([OH:20])[CH2:15][CH2:14][C:13]2(OCC[O:16]2)[CH2:12][CH2:11]1>C(O)(=O)C.Cl>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1([OH:20])[CH2:11][CH2:12][C:13](=[O:16])[CH2:14][CH2:15]1

참가 물질

4

반응물 1

HCID 110875818-(2-Benzothiazolyl)-1,4-dioxaspiro[4.5]decan-8-ol

생성물 1

HCID 98136284-(Benzothiazol-2-yl)-4-hydroxycyclohexan-1-one수율 73.5%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매

실험 절차

A solution of 4-(benzothiazol-2-yl)-1,1-ethylenedioxy-4-hydroxycyclohexane (1.0 g, 3.4 mmol) in acetic acid (40 mL) and conc. HCl (10 mL) was heated at 80° C. for 2 h with stirring. The volume was reduced on a rotary evaporator and the remaining solution was carefully neutralized with saturated sodium hydrogen carbonate solution and then extracted with diethyl ether (3×50 mL). The organic layers were combined, washed with water (2×50 mL) and dried over magnesium sulphate. Removal of the solvent under vacuum gave the product 4-(benzothiazol-2-yl)-4-hydroxycyclohexan-1-one (0.618 g) as an off white solid (73%); mp 134° C.; 1H NMR (CDCl3) δ 8.00 (1H, m, benzothiazole H-4/7), 7.91 (1H, m, benzothiazole H-4/7), 7.49 (1H, m, benzothiazole H-5/6), 7.41 (1H, m, benzothiazole H-5/6), 3.66 (1H, s, OH), 2.97–2.85 (4H, m, cyclohexanone CH2), 2.53–2.34 (4H, m, cyclohexanone CH2); IR (KBr disc) 2913, 1690, 1505, 1427, 1312, 1198, 889, 768 cm−1; MS (AP+) 248 (M++1), 230 (M++1—H2O); Anal. (C13H13NO2S) C, H, N.

후처리

  1. customThe volume was reduced on a rotary evaporator
  2. extractionextracted with diethyl ether (3×50 mL)
  3. washwashed with water (2×50 mL)
  4. dry with materialdried over magnesium sulphate
  5. customRemoval of the solvent under vacuum

출처 및 근거

ORD 기록
ord-5271f06408424c3ea73d7df168def07a
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144893B2

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