1,3-Dichloroacetone → (4-Chloromethyl-thiazol-2-yl)-naphthalen-1-yl-amine

HRID 857080

반응식

HRID 857080 반응식
[C:1]1([NH:11][C:12]([NH2:14])=[S:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:15][CH2:16][C:17]([CH2:19]Cl)=O>CC(C)=O>[Cl:15][CH2:16][C:17]1[N:14]=[C:12]([NH:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)[S:13][CH:19]=1

참가 물질

4

반응물 2

HCID 107931,3-DichloroacetoneHCID 736366Alpha-Naphthylthiourea

생성물 1

HCID 21866567(4-Chloromethyl-thiazol-2-yl)-naphthalen-1-yl-amine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of naphthalen-1-yl-thiourea (iii) (2.02 g, 10 mmol) in acetone (50 mL) at room temperature was added 1,3-dichloroacetone (1.03 g, 10.5 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered and washed with methanol. The filtrate was treated with hexane to afford a white precipitate. The precipitate was filtered and washed with hexane.

후처리

  1. filtrationThe reaction mixture was filtered
  2. washwashed with methanol
  3. additionThe filtrate was treated with hexane
  4. customto afford a white precipitate
  5. filtrationThe precipitate was filtered
  6. washwashed with hexane

출처 및 근거

ORD 기록
ord-01f4098aa1b34fafbb1a2eada84a92d2
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144903B2

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