Potassium Carbonate → HCID 69344724, 화합물
반응식
[NH2:1][C:2]([NH:4][C@@:5]([CH3:18])([C:14](OC)=[O:15])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([I:13])[CH:8]=1)=[O:3].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.CCOC(C)=O>[I:13][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[CH2:6][C@@:5]1([CH3:18])[NH:4][C:2](=[O:3])[NH:1][C:14]1=[O:15]참가 물질
5
반응 조건
- 온도
- 110 °C
실험 절차
A mixture of methyl N-(aminocarbonyl)-3-iodo-α-methyl-D-phenylalaninate (0.82 g) and potassium carbonate (624 mg) in dimethyl sulfoxide (5 ml) was heated to 110° C. for 3 h and then allowed to cool to 20° C. overnight. The mixture was diluted with EtOAc and washed with 2M HCl, brine, dried (MgSO4) and evaporated to dryness to give the title compound (521 mg) LCMS RT=2.61 min
후처리
- temperatureto cool to 20° C. overnight
- washwashed with 2M HCl, brine
- dry with materialdried (MgSO4)
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-d9dd831e51c042228e3c86ce9d11d43e
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144908B2
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