Hydrochloric Acid → 1-(3-Iodobenzyl)imidazolidine-2,4-dione

반응식

[I:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][NH:6][CH2:7][C:8]([O:10]CC)=O.Cl.[O-:17][C:18]#[N:19].[Na+]>>[I:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][N:6]1[CH2:7][C:8](=[O:10])[NH:19][C:18]1=[O:17]

참가 물질

반응물 3

HCID 313Hydrochloric Acid2회

HCID 517096Sodium Cyanate

HCID 21867201Ethyl N-(3-iodobenzyl)glycinate

생성물 1

HCID 218670381-(3-Iodobenzyl)imidazolidine-2,4-dione수율 96.7%

실험 절차

Ethyl N-(3-iodobenzyl)glycinate (0.567 g) was treated with 1M HCl (3.9 ml) and sodium cyanate (0.345 g) and then refluxed for 30 min. Concentrated HCl (4.5 ml) was added and the reaction mixture refluxed again for 30 min. The reaction mixture was evaporated under reduced pressure and then triturated with EtOAc (3×20 ml). The combined extracts were dried (Na2SO4) and evaporated under reduced pressure to give the title compound (0.543 g). LCMS RT 2.63 min.