Ethanol → Ethyl 2-{[(3-iodophenyl)amino]carbonyl}hydrazinecarboxylate
반응식
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[NH:2][NH2:3].[I:8][C:9]1[CH:10]=[C:11]([N:15]=[C:16]=[O:17])[CH:12]=[CH:13][CH:14]=1.C(O)C>ClCCl>[I:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH:3][NH:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:17])[CH:12]=[CH:13][CH:14]=1참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
A solution of ethyl carbazate (1.25 g) in dichloromethane (20 ml) was treated with 3-iodophenylisocyanate (1.7 g) at 0° C. The reaction mixture was allowed to warm to 20° C. and stirred for 2 h. Ethanol (2 ml) was added and the mixture was stirred for 0.5 h. The solvents were removed under reduced pressure and the residue was triturated in diethyl ether. The white solid was collected by filtration to give the title compound (2.4 g). LCMS RT=2.81 min
후처리
- stirringthe mixture was stirred for 0.5 h
- customThe solvents were removed under reduced pressure
- customthe residue was triturated in diethyl ether
- filtrationThe white solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-e603dd6d9b484b44a170870b3bcfc6ce
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144908B2
반응 노트
불러오는 중…