Hydrochloric Acid → Benzyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 857174노트

반응식

HRID 857174 반응식
[CH2:1]1[CH:5]2[CH2:6][N:7](C(OC(C)(C)C)=O)[CH2:8][CH:4]2[CH2:3][N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17].Cl.C([O-])([O-])=O.[K+].[K+].O>C(OCC)(=O)C>[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 218675632-Benzyl 5-(tert-butyl) tetrahydropyrrolo[3,4-C]pyrrole-2,5(1H,3H)-dicarboxylate

생성물 1

HCID 21867560Benzyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate수율 82%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

Benzyl tert-butyl tetrahydropyrrolo[3,4-c]pyrrole-2,5(1H, 3H)-dicarboxylate (40 mmol; from step (a) above) was dissolved in ethyl acetate. Ethyl acetate saturated with HCl (g) (500 mL) was added at 0° C. and stirred while reaching room temperature. The solvent was evaporated and the product was dissolved in CH3CN. K2CO3 (4 eq.) and water (2 mL) were added. The mixture was stirred for 2 h, before being filtered and evaporated to give 8 g (82%) of the subtitle compound which was used without further purification in the next step.

후처리

  1. customwhile reaching room temperature
  2. customThe solvent was evaporated
  3. dissolutionthe product was dissolved in CH3CN
  4. stirringThe mixture was stirred for 2 h
  5. filtrationbefore being filtered
  6. customevaporated

출처 및 근거

ORD 기록
ord-946780d4b33d459dac26277b2c390ae6
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144914B2

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