Hydrochloric Acid → 4-(Methanesulfonyl)piperidine

HRID 85731노트

반응식

HRID 85731 반응식
[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].Cl>C1COCC1>[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22504298Tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate

생성물 1

HCID 222750384-(Methanesulfonyl)piperidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
20 °C

실험 절차

A mixture of tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate (1.5 g, 5.70 mmol) and hydrogen chloride (7.12 mL, 28.5 mmol) in THF (20 mL) was stirred at 20° C. for 15 hours. TLC indicated the formation of desired product, the reaction mixture was filtered and the pale yellow solid was collected to provide desired product (1 g, 88%). LCMS: m/e 163.96 (M+H)+, 0.25 min (method 10).

출처 및 근거

ORD 기록
ord-fe60ead0482c4a67a8aa2f5848de269c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846647B2

반응 노트

불러오는 중…