Benzylamine → 3-Benzyl-8-oxa-3-azabicyclo[3.2.1]octane

HRID 8580노트

반응식

HRID 8580 반응식
CC1C=CC(S(O[CH2:12][CH:13]2[O:17][CH:16]([CH2:18]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:15][CH2:14]2)(=O)=O)=CC=1.[CH2:30]([NH2:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>C1(C)C=CC=CC=1>[CH2:30]([N:37]1[CH2:12][CH:13]2[O:17][CH:16]([CH2:15][CH2:14]2)[CH2:18]1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 259634(Tetrahydrofuran-2,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

생성물 1

HCID 120692303-Benzyl-8-oxa-3-azabicyclo[3.2.1]octane

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

112 g (250 mmol) of 2,5-anhydro-3,4-dideoxy-1,6-bis-O-[(4-methylphenyl)sulfonyl]-hexitol from step 1 and 90.7 g (840 mmol) of benzylamine in 500 ml of toluene are heated under reflux for 20 hours. The precipitate is then filtered off with suction and washed with toluene. The combined toluene phases are concentrated in a rotary evaporator and distilled in vacuo. After a benzylamine fore-run, the product is obtained.

후처리

  1. temperatureunder reflux for 20 hours
  2. filtrationThe precipitate is then filtered off with suction
  3. washwashed with toluene
  4. concentrationThe combined toluene phases are concentrated in a rotary evaporator
  5. distillationdistilled in vacuo

출처 및 근거

ORD 기록
ord-f28c838693d64d378a2dbf9cdb185727
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091198B1

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