Trifluoroacetic anhydride → 2,2-Dimethyl-6-[3-(2-methyl-imidazol-1-yl)-phenyl]-[1,3]dioxin-4-one

HRID 859379노트

반응식

HRID 859379 반응식
[C:1]([O:5][C:6](=[O:22])[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[CH3:21])[CH:11]=1)=[O:9])(C)([CH3:3])[CH3:2].C(OC(C(F)(F)F)=O)(C(F)(F)F)=O>C(O)(C(F)(F)F)=O.CC(C)=O>[CH3:2][C:1]1([CH3:3])[O:5][C:6](=[O:22])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N:16]3[CH:20]=[CH:19][N:18]=[C:17]3[CH3:21])[CH:11]=2)[O:9]1

참가 물질

4

반응물 2

HCID 9845Trifluoroacetic anhydrideHCID 695927863-[3-(2-Methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

생성물 1

HCID 222247902,2-Dimethyl-6-[3-(2-methyl-imidazol-1-yl)-phenyl]-[1,3]dioxin-4-one

시약·촉매·용매 1

HCID 86586799TFA acetone용매

실험 절차

Prepared from 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (Example H8) by stirring in TFA/acetone with TFAA according to general procedure J (method b). Obtained as a beige solid (2.13 g).

출처 및 근거

ORD 기록
ord-12f3bef4585e44dda2f4b58fcbde1e3e
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151098B2

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