Diethyl Ether → Pyridine-4-amidine hydrochloride

HRID 8595

반응식

HRID 8595 반응식
[Na].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)#[N:3].[Cl-:10].[NH4+:11].C(OCC)C>CO>[ClH:10].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=[NH:11])[NH2:3]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 75064-CyanopyridineHCID 25517Ammonium ChlorideHCID 5360545Sodium

생성물 1

HCID 2776844Pyridine-4-amidine hydrochloride수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at room temperature. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed once with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.

후처리

  1. stirringstirring
  2. waitwas continued for another 10 h
  3. filtrationthe precipitate was filtered off after 30 min
  4. washwashed once with diethylether (20 ml)
  5. customThe product was dried under high vacuum

출처 및 근거

ORD 기록
ord-f98f5a335bf343b985a425cce2db865f
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091201B2

연결된 노트

불러오는 중…