Phenylacetylene → 4-(Phenylethynyl)benzaldehyde

HRID 859861

반응식

HRID 859861 반응식
Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[C:10]1([C:16]#[CH:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(N(CC)CC)C>[C:10]1([C:16]#[C:17][C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 10821PhenylacetyleneHCID 707414-Bromobenzaldehyde

생성물 1

HCID 6099084-(Phenylethynyl)benzaldehyde수율 63%

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
80 °C

실험 절차

4-Bromobenzaldehyde (370 mg, 2 mmol), phenylacetylene (306 mg, 3 mmol) and tetrakistriphenylphosphine palladium (45 mg) were dissolved in triethylamine (4 ml), and the obtained solution was stirred at 80° C. in argon atmosphere for 24 hours. The solvent was evaporated, and the product was purified by the silica gel column chromatography to obtain 4-(2-phenylethynyl)benzaldehyde (yield: 258 mg, 63%)

후처리

  1. customThe solvent was evaporated
  2. customthe product was purified by the silica gel column chromatography

출처 및 근거

ORD 기록
ord-c6503ad896b248589942d3d07b72e6b8
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153850B2

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