Piperazine → 6-Bromoquipazine

HRID 860009

반응식

HRID 860009 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[CH:6]=[CH:5]2.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CN(C)C=O.C(=O)(O)[O-].[Na+]>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH:6]=[CH:5]2

참가 물질

5

반응물 2

HCID 4837PiperazineHCID 128940866-Bromo-2-chloroquinoline

생성물 1

HCID 1302616-Bromoquipazine

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 516892Sodium Bicarbonate용매

반응 조건

온도
110 °C

실험 절차

To a solution of 6-bromo-2-chloroquinoline of Step A (1.25 g, 5.15 mmol) in N,N-dimethylformamide (35 mL) is added piperazine (4.43 g, 51.4 mmol) and the mixture is heated at 110° C. under nitrogen for 3 hours. After cooling, it is diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extracts are dried over anhydrous magnesium sulfate and evaporated to dryness.

후처리

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extracts are dried over anhydrous magnesium sulfate
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-0968b3c8b57a4bc28a0ab591d4bbdb7e
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153849B2

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