참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 6-Bromo-2-chloroquinoline | HCID 12894086 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 6-Bromoquipazine | HCID 130261 | — |
반응 단계
To a solution of 6-bromo-2-chloroquinoline of Step A (1.25 g, 5.15 mmol) in N,N-dimethylformamide (35 mL) is added piperazine (4.43 g, 51.4 mmol) and the mixture is heated at 110° C. under nitrogen for 3 hours. After cooling, it is diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extracts are dried over anhydrous magnesium sulfate and evaporated to dryness.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07153849B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_12 |
|---|
| ORD ID | ord-0968b3c8b57a4bc28a0ab591d4bbdb7e |
|---|
| 출처 메모 | uspto-grants-2006_12 |
|---|
