反应详情

温度

110 °C

To a solution of 6-bromo-2-chloroquinoline of Step A (1.25 g, 5.15 mmol) in N,N-dimethylformamide (35 mL) is added piperazine (4.43 g, 51.4 mmol) and the mixture is heated at 110° C. under nitrogen for 3 hours. After cooling, it is diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extracts are dried over anhydrous magnesium sulfate and evaporated to dryness.

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. dry with materialThe extracts are dried over anhydrous magnesium sulfate
4. customevaporated to dryness