Acetic Anhydride → 6-Fluoro-1,2-dihydroquinolin-2-one

HRID 860022노트

반응식

HRID 860022 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N+:8]([O-])=[CH:7][CH:6]=[CH:5]2.C(OC(=O)C)(=[O:15])C>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:15])[CH:6]=[CH:5]2

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 198986466-Fluoro-1-oxo-1lambda~5~-quinoline

생성물 1

HCID 98340436-Fluoro-1,2-dihydroquinolin-2-one

실험 절차

A solution of 6-fluoroquinoline 1-oxide from Step B (5.0 g, 30.65 mmol) in acetic anhydride (30 mL) is heated at 110° C. for 6.5 hours. The reaction is allowed to stand at room temperature overnight. The solid (1.1 g) is collected and recrystallized from anhydrous ethanol (75 mL). The reddish crystals are collected by filtration and dried under high vacuum to give the title compound (0.653 g), m.p. dec. 269–270° C.

후처리

  1. customThe solid (1.1 g) is collected
  2. customrecrystallized from anhydrous ethanol (75 mL)
  3. filtrationThe reddish crystals are collected by filtration
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-426482cb18f346cc95904b856e8a76d2
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153849B2

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