Propionic Acid → (+/-)9-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-3-quinoxalin-2-yl-non-4-enoic acid ethyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Propionic Acid	HCID 1032	—
반응물	Triethyl orthoacetate	HCID 66221	—
반응물	(+/-)7-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-1-quinoxalin-2-yl-hept-1-en-3-ol	HCID 69665953	—
반응물	Hydrochloric acid brine	HCID 131718760	—
생성물	(+/-)9-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-3-quinoxalin-2-yl-non-4-enoic acid ethyl ester	HCID 69666596	48%

반응 조건

온도	150 °C

반응 단계

A solution of the allylic alcohol 22-3 (0.26 g, 0.57 mmol) in (EtO)3CMe (10 mL) was treated with 100 μL of a 1 mL solution of (EtO)3CMe containing 10 μL of propionic acid. The yellow solution was heated at 150° C. for 90 minutes. The solution was cooled to room temperature and poured into 1N HCl/brine. The mixture was extracted with CHCl3, dried, concentrated, and purified on silica gel (90:5:5 CHCl3:EtOAc:MeOH) to give 0.143 g (48%) of 22-4.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07153862B2
출처 데이터셋	uspto-grants-2006_12
ORD ID	ord-9f0c2d2ae3554ba4842efdb93e0c1261
출처 메모	uspto-grants-2006_12