Sodium Hydroxide → n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

HRID 860178노트

반응식

HRID 860178 반응식
C([O:8][C:9](=[O:29])[CH:10]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[NH:22])[NH2:21])=[CH:16][CH:15]=1)=[O:12])C1C=CC=CC=1.[OH-].[Na+:31]>C1COCC1>[Na+:31].[C:20]([C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:11](=[O:12])[CH:10]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:9]([O-:29])=[O:8])=[CH:19][CH:18]=1)(=[NH:21])[NH2:22]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10110753HCID 10110753, 화합물

생성물 1

HCID 23700157n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

8.26 g (19.5 mmol) of the benzyl ester from example 1 were dissolved in 100 ml THF and stirred overnight with 20 ml 2 M aqueous NaOH. The solvent was removed after filtration, water was added, and the solution extracted with diethyl ether. The aqueous phase was freeze dried and sufficiently pure for further derivatization.

후처리

  1. customThe solvent was removed
  2. filtrationafter filtration, water
  3. additionwas added
  4. extractionthe solution extracted with diethyl ether
  5. customdried and sufficiently pure for further derivatization

출처 및 근거

ORD 기록
ord-80021ebbbb5a4ec49a4f9333d7dfcb19
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153876B2

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