Hydroxide → 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

HRID 860418노트

반응식

HRID 860418 반응식
[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-]>CO>[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:23][CH:24]=1)(=[O:13])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 961HydroxideHCID 57444531Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate

생성물 1

HCID 574445324-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of methyl 4-({[(benzyloxy)carbonyl]amino}-sulfonyl)benzoate (3.38 g) and 85% pottasium hydroxide (1.28 g) in methanol (40 mL) was stirred for 35 minutes. Methanol was evaporated off, and to the mixture was added 1N hydrochloric acid (20 mL). A white crystal was formed, which was collected by filtration and washed with water and diisopropyl ether, and dried under vacuum. 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid was obtained as a white crystal (2.92 g).

후처리

  1. customMethanol was evaporated off
  2. additionto the mixture was added 1N hydrochloric acid (20 mL)
  3. customA white crystal was formed
  4. filtrationwhich was collected by filtration
  5. washwashed with water and diisopropyl ether
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-19b9584d9c8340e582a20435db42069a
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153854B2

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