Potassium Carbonate → HCID 69019515, 화합물

HRID 860784

반응식

HRID 860784 반응식
C([O-])([O-])=O.[K+].[K+].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[O:18][CH2:17][CH2:16][O:15]2)=[CH:10][C:9]=1[CH:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)[OH:27].[Br:35][CH2:36][C:37](Br)=[O:38]>C(Cl)Cl>[Br:35][CH2:36][C:37]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([C:19]3[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[O:18][CH2:17][CH2:16][O:15]2)=[CH:10][C:9]=1[CH:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)[OH:27])=[O:38]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 61147Bromoacetyl bromideHCID 690198082-Amino-alpha-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-benzenemethanol

생성물 1

HCID 69019515HCID 69019515, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

K2CO3 10% (250 ml) was added to a mixture of intermediate (9) (0.072 mol) in DCM (250 ml). Then bromo-acetyl bromide (0.072 mol) was added dropwise at room temperature. The mixture was stirred at room temperature overnight. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated till dryness. The product was used without further purification, yielding (quant.) of 2-bromo-N-[4-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2-[(3-chlorophenyl)hydroxymethyl]phenyl]-acetamide (intermediate 10).

후처리

  1. customThe organic layer was separated
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe solvent was evaporated till dryness
  5. customThe product was used without further purification

출처 및 근거

ORD 기록
ord-53f0595b634948e0813ef477d7935be0
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153958B2

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