참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | Venlafaxine | HCID 5656 | — |
| 반응물 | Sodium benzenethiol | HCID 66586497 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Desvenlafaxine | HCID 125017 | — |
반응 단계
Venlafaxine (5.6 g) and benzenethiol sodium salt (6.9 g) are charged to PEG 400 (25 g). The reaction mixture is heated to 160° C. for 5 hours. Then the temperature is lowered and water is added (60 g). The pH is adjusted to 3.5 with H3PO4. The organic by-products are removed by extraction with heptanes (25 g). The pH of the aqueous layer is then adjusted to 9.5 with aqueous ammonia. The precipitate is collected by suction filtration, re-slurried in water (100 g), isolated by suction filtration and dried in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07154001B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_12 |
|---|
| ORD ID | ord-45fafbe0bbc64b9b947cd0b54ba8fe40 |
|---|
| 출처 메모 | uspto-grants-2006_12 |
|---|
