Venlafaxine → Desvenlafaxine

HRID 860915

반응식

HRID 860915 반응식
C(S)CCCCCCCCCCC.[CH3:14][N:15]([CH2:17][CH:18]([C:27]1([OH:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:19]1[CH:20]=[CH:21][C:22]([O:25]C)=[CH:23][CH:24]=1)[CH3:16].C([O-])C.[Na+]>>[CH3:14][N:15]([CH2:17][CH:18]([C:27]1([OH:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:19]1[CH:20]=[CH:21][C:22]([OH:25])=[CH:23][CH:24]=1)[CH3:16]

참가 물질

4

반응물 3

HCID 5656VenlafaxineHCID 81951-DodecanethiolHCID 2723922Sodium ethoxide

생성물 1

HCID 125017Desvenlafaxine

반응 조건

온도
150 °C

실험 절차

Dodecanethiol (69 g), venlafaxine (55 g), and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.

후처리

  1. filtrationthe solution is filtered
  2. filtrationThe crystals are collected by suction filtration
  3. washThe cake is washed with ethanol
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-1f210c72ef1d4d6dbed5314b68ac8d0c
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07154001B2

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