Isopropyl isocyanate → HCID 901017, 화합물

HRID 861009노트

반응식

HRID 861009 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.C1CCN2C(=NCCC2)CC1.[CH:20]([N:23]=[C:24]=[O:25])([CH3:22])[CH3:21]>C(Cl)Cl>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:24]([NH:23][CH:20]([CH3:22])[CH3:21])=[O:25])=[N:3][CH:4]=1

참가 물질

5

반응물 3

HCID 61277Isopropyl isocyanateHCID 706222-Amino-5-bromopyridineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

생성물 1

HCID 901017HCID 901017, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-amino-5-bromo-pyridine (1.05 eq.) in TBF (0.2M) was added DBU (1.0 eq.) followed by iso-propyl-isocyanate (1.0 eq.). The mixture was stirred for 12 h, diluted with CH2Cl2, washed with brine, dried over MgSO4, filtered and concentrated. Crystallization from acetone afforded the title compound as a white solid.

후처리

  1. washwashed with brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customCrystallization from acetone

출처 및 근거

ORD 기록
ord-3f06e1b7e3ca49f1a12089c09a323654
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153968B2

반응 노트

불러오는 중…