Hydrogen Peroxide → 4-Phenyl-3-(4-pyridyl)-3,4-epoxy-2-butanone
반응식
[C:1]1([CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:9](=[O:11])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:18]O.[OH-].[Na+]>CO>[C:1]1([CH:7]2[O:18][C:8]2([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:9](=[O:11])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
5
실험 절차
Using the procedure of Example A-1, step 2, a solution of 4-phenyl-3-(4-pyridyl)-3-butene-2-one (step 2) (1.25 g, 5.6 mmol) in methanol (20 ml) was treated with 30% aqueous hydrogen peroxide (1 ml) in the presence of sodium hydroxide (230 mg, 5.7 mmol). The crude product was purified by chromatography (silica gel, 1:1 ethyl acetate/hexane) to give 4-phenyl-3-(4-pyridyl)-3,4-epoxy-2-butanone (270 mg, 20%).
후처리
- customThe crude product was purified by chromatography (silica gel, 1:1 ethyl acetate/hexane)
출처 및 근거
- ORD 기록
- ord-d5973da4321541e2b0852ac87efbef45
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07153959B2
반응 노트
불러오는 중…