Pyrrolidine → HCID 57494734, 화합물

HRID 861123노트

반응식

HRID 861123 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]([C:18](=[O:20])[CH3:19])=[C:11]3[CH:12]=[CH:13][CH:14]=[C:15](Cl)[N:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]([C:18](=[O:20])[CH3:19])=[C:11]3[CH:12]=[CH:13][CH:14]=[C:15]([N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)[N:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 574447271-[2-(3-Bromophenyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]ethanone

생성물 1

HCID 57494734HCID 57494734, 화합물수율 96%

실험 절차

In a similar manner as described in Example 1 from 1-[2-(3-bromophenyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]ethanone (3.00 g, 8.6 mmol) and pyrrolidine, 1-[2-(3-bromophenyl)-7-(1-pyrrolidinyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone (3.18 g, 96%) was obtained as a yellow syrup. 1H NMR (CDCl3): δ 7.78–7.74 (m, 2H), 7.56 (d, 1H), 7.50 (d, 1H), 7.38–7.28 (m, 2H), 6.14 (d, 1H), 3.72 (m, 4H), 2.12 (s, 3H), 1.98 (m, 4H); MS m/z 384 (M+1).

출처 및 근거

ORD 기록
ord-da663f77b0d34bdd8bb48311f53a9ca7
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153855B2

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