Hydrochloric Acid → N1-hexanoylsulfanilamide

HRID 861186

반응식

HRID 861186 반응식
C(NC1C=CC(S(N)(=O)=O)=CC=1)(=O)C.C(Cl)(=O)CCCCC.Cl.C([NH:27][C:28]1[CH:44]=[CH:43][C:31]([S:32]([NH:35][C:36](=[O:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:34])=[O:33])=[CH:30][CH:29]=1)(=O)C>O.N1C=CC=CC=1>[C:36]([NH:35][S:32](=[O:33])([C:31]1[CH:30]=[CH:29][C:28]([NH2:27])=[CH:44][CH:43]=1)=[O:34])(=[O:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8482N4-AcetylsulfanilamideHCID 67340Hexanoyl chlorideHCID 54008860HCID 54008860, 화합물

생성물 1

HCID 14338356N1-hexanoylsulfanilamide

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

실험 절차

N1 -hexanoylsulfanilamide was prepared as follows. To a mixture of N4 -acetylsulfanilamide (55.0 g) and pyridine (54 mL) at 95° C. was added hexanoyl chloride (28.8 g) over a period of 20 min. After an additional hour the reaction mixture was cooled to room temperature and the reaction was worked up by diluting with 600 mL D.I. water and acidifying with aqueous HCl. The product of this reaction, N4 -acetyl-N1 -hexanoylsulfanilamide, was isolated by filtration and washed with D.I. water (700 mL) to afford an off-white solid. This material was carried directly to the next step.

후처리

  1. additionby diluting with 600 mL D.I
  2. customwas isolated by filtration
  3. washwashed with D.I
  4. customwater (700 mL) to afford an off-white solid

출처 및 근거

ORD 기록
ord-4ae0af2c5247494da797655fdc01bac6
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05713988

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