Diethyl Oxalate → 1-cyclohexyl-6-trifluoromethyl-2,3(1H,4H)-quinoxalinedione

반응식

[CH:1]1([NH:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=2[NH2:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:19](OCC)(=[O:25])[C:20](OCC)=[O:21]>>[CH:1]1([N:7]2[C:8]3[C:9](=[CH:11][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:13][CH:14]=3)[NH:10][C:20](=[O:21])[C:19]2=[O:25])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

반응물 2

HCID 7268Diethyl Oxalate

HCID 24165451-N-cyclohexyl-4-(trifluoromethyl)benzene-1,2-diamine

생성물 1

HCID 220971991-cyclohexyl-6-trifluoromethyl-2,3(1H,4H)-quinoxalinedione

실험 절차

28 g (0.11 mol) of 2-cyclohexylamino-5-trifluoromethylaniline and 322 g (2.2 mol) of diethyl oxalate were refluxed for 2 hours. The reaction mixture was then concentrated, and the crude product was recrystallized from ethanol.

후처리

concentrationThe reaction mixture was then concentrated
customthe crude product was recrystallized from ethanol

출처 및 근거

ORD 기록: ord-786e503dc11b480e8da3e4114a427d4c
출처 데이터셋: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05714489

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