Cornforth reagent → 5-Bromo-2-ethoxybenzaldehyde

HRID 861622

반응식

HRID 861622 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH3:12])=[C:6]([CH:9]=1)[CH2:7][OH:8].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH3:12])=[C:6]([CH:9]=1)[CH:7]=[O:8]

참가 물질

4

반응물 2

HCID 2724130Cornforth reagentHCID 24721639(5-Bromo-2-ethoxyphenyl)methanol

생성물 1

HCID 1449015-Bromo-2-ethoxybenzaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5-Bromo-2-ethoxybenzyl alcohol (2.78 g, 12.0 mmol) and pyridinium dichromate (4.51 g, 12.0 mmol) in 120 ml of CH2Cl2 was stirred at RT for 6 h. The mixture was filtered, washed with H2O, 0.5N HCl and brine and dried over Na2SO4. The product was purified by silica gel column chromatography (EtOAc/petroleum ether 10:100) to give 5-bromo-2-ethoxybenzaldehyde.

후처리

  1. filtrationThe mixture was filtered
  2. washwashed with H2O, 0.5N HCl and brine
  3. dry with materialdried over Na2SO4
  4. customThe product was purified by silica gel column chromatography (EtOAc/petroleum ether 10:100)

출처 및 근거

ORD 기록
ord-14ed117b41fe4638a869c64991c7f68e
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05714503

연결된 노트

불러오는 중…