Hydrochloric Acid → 4-Cyclohexyl-gamma-oxobenzenebutanoic acid

HRID 861864노트

반응식

HRID 861864 반응식
[CH:1]1([C:7]2[CH:21]=[CH:20][C:10]([C:11]([CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.Cl>CO.[OH-].[K+]>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])=[CH:20][CH:21]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 14903180HCID 14903180, 화합물

생성물 1

HCID 1618624-Cyclohexyl-gamma-oxobenzenebutanoic acid수율 61%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14797Potassium Hydroxide용매

실험 절차

To a solution of ethyl 3-(4-cyclohexylbenzoyl)propionate (19.6 g) in methanol (150 ml), 2N KOH (102 ml) was added, followed by stirring at room temperature for 1.5 hours. The reaction mixture was poured into water (200 ml), acidified with concentrated hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried (MgSO4), after which the solvent was evaporated off, to yield 3-(4-cyclohexylbenzoyl)propionic acid (10.8 g, 61%), which was then recrystallized from isopropyl ether to yield colorless prisms having a melting point of 140°-141° C.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with water
  3. dry with materialdried (MgSO4)
  4. customafter which the solvent was evaporated off

출처 및 근거

ORD 기록
ord-3410177dbdfc4c0e8d13c898681659bf
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716944

반응 노트

불러오는 중…