Ethanol → (5-Nitrothiophen-2-yl)methanol
반응식
[BH4-].[Na+].[N+:3]([C:6]1[S:10][C:9]([CH:11]=[O:12])=[CH:8][CH:7]=1)([O-:5])=[O:4].C(O)C>O>[OH:12][CH2:11][C:9]1[S:10][C:6]([N+:3]([O-:5])=[O:4])=[CH:7][CH:8]=1참가 물질
5
실험 절차
Sodium borohydride (0.24 g) was added to a mixture of 5-nitro-2-thiophenecarboxaldehyde (1.0 g) and ethanol (30 ml) at 0° C. and then this mixture was stirred at the same temperature for 40 minutes. The reaction mixture was poured into water and extracted with dichloromethane. The dichloromethane layer was washed with water and dried (MgSO4), after which the solvent was evaporated off, to yield 2-hydroxymethyl-5-nitrothiophene (0.5 g, 49%).
후처리
- extractionextracted with dichloromethane
- washThe dichloromethane layer was washed with water
- dry with materialdried (MgSO4)
- customafter which the solvent was evaporated off
출처 및 근거
- ORD 기록
- ord-fef0c22ab45f4222947122e29012b79a
- 출처 데이터셋
- uspto-grants-1998_02
- 특허 번호
- US05716944
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