2-Fluorobenzophenone → (2-Fluorophenyl)(phenyl)methanol

HRID 861901

반응식

HRID 861901 반응식
[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[OH:5]

참가 물질

4

반응물 2

HCID 676502-FluorobenzophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 10584252(2-Fluorophenyl)(phenyl)methanol수율 99%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Fluorobenzophenone (15.0 g) is dissolved in ethanol and sodium borohydride (3.8 g) is added in portions and the mixture is stirred for 20 hours. The reacted solution is concentrated under reduced pressure and extracted with chloroform and water to give crude (2-fluorophenyl)phenylmethanol (15.0 g) (quantitative) as colorless liquid.

후처리

  1. concentrationThe reacted solution is concentrated under reduced pressure
  2. extractionextracted with chloroform and water

출처 및 근거

ORD 기록
ord-c9141cfb5aeb445e97fcde16004fb780
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716950

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