Sodium borohydride → Benzenemethanol, 5-bromo-2-(methoxymethoxy)-

HRID 862056노트

반응식

HRID 862056 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][O:12][CH3:13])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][O:12][CH3:13])=[C:6]([CH:9]=1)[CH2:7][OH:8]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 197016265-Bromo-2-(methoxymethoxy)benzaldehyde

생성물 1

HCID 54142346Benzenemethanol, 5-bromo-2-(methoxymethoxy)-수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-bromo-2-methoxymethoxybenzaldehyde (5.00 g) in methanol (50 ml) was added, at 0° C., sodium borohydride (0.46 g). The mixture was stirred for 30 minutes at the same temperature, which was then concentrated. To the concentrate was added ethyl acetate, and the mixture was washed with an aqueous solution of potassium hydrogensulfate and a saturated aqueous saline solution, successively. The organic layer was dried (anhydrous magnesium sulfate), which was then concentrated to leave 5-bromo-2-methoxymethoxybenzyl alcohol (5.04 g) as a pale yellow oily product.

후처리

  1. concentrationwas then concentrated
  2. additionTo the concentrate was added ethyl acetate
  3. washthe mixture was washed with an aqueous solution of potassium hydrogensulfate
  4. dry with materialThe organic layer was dried (anhydrous magnesium sulfate), which
  5. concentrationwas then concentrated

출처 및 근거

ORD 기록
ord-0a810795ea7145fd8dc67a46d3fa7d98
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716971

반응 노트

불러오는 중…