Hydrochloric Acid → HCID 10568313, 화합물

HRID 862075노트

반응식

HRID 862075 반응식
[Br:1][C:2]1[C:3]([Cl:24])=[CH:4][C:5]([O:20]COC)=[C:6]([CH:19]=1)[C:7]([C:9]1[C:14]([O:15]COC)=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:8].Cl>CO>[Br:1][C:2]1[C:3]([Cl:24])=[CH:4][C:5]([OH:20])=[C:6]([CH:19]=1)[C:7]([C:9]1[C:14]([OH:15])=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 108357432-(5-Bromo-4-chloro-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine

생성물 1

HCID 10568313HCID 10568313, 화합물수율 97.6%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of 2-(5-bromo-4-chloro-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine (7.73 g) in methanol (250 ml) was added hydrochloric acid (12.5 ml), which was stirred for 5 hours at 50° C. Methanol was distilled off under reduced pressure. To the residue was added ethyl acetate (5 ml), which was poured into water. Crystalline precipitate then formed was collected by filtration, washed with ethyl acetate 10 and dried to give 2-(5-bromo-4-chloro-2-hydroxybenzoyl)-3-hydroxypyridine (5.95 g) (Compound A-8).

후처리

  1. distillationMethanol was distilled off under reduced pressure
  2. additionTo the residue was added ethyl acetate (5 ml), which
  3. additionwas poured into water
  4. customCrystalline precipitate then formed
  5. filtrationwas collected by filtration
  6. washwashed with ethyl acetate 10
  7. customdried

출처 및 근거

ORD 기록
ord-cb31bb7f5900478c8ebe2f3eca5bbab7
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716971

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