Pyridine → 6-amino-2-methylpyridazine-3(2H)-thione
반응식
N1C=CC=CC=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:16])=CC=1.[NH2:29][C:30]1[CH:35]=[CH:34][C:33](=O)[N:32]([CH3:37])[N:31]=1.C(Cl)(Cl)Cl>CO>[NH2:29][C:30]1[CH:35]=[CH:34][C:33](=[S:16])[N:32]([CH3:37])[N:31]=1참가 물질
6
실험 절차
Pyridine (5 ml) and a Lawesson's reagent (970 mg, 2.4 mmol) were added to 3-amino-1-methyl-1,6-dihydropyridazin-6-one (500 mg, 4 mmol) as described in Journal of Medicinal Chemistry, 34 (10), 3074 (1991), and the mixture was refluxed under heating for 5 hours. The reaction mixture was concentrated and the residue obtained was subjected to silica gel column chromatography (chloroform:methanol=100:1) to give 218 mg of 3-amino-1-methyl-1,6-dihydropyridazine-6-thione.
후처리
- temperaturethe mixture was refluxed
- temperatureunder heating for 5 hours
- concentrationThe reaction mixture was concentrated
- customthe residue obtained
출처 및 근거
- ORD 기록
- ord-8669ca35e835445da07adb346df577bd
- 출처 데이터셋
- uspto-grants-1998_02
- 특허 번호
- US05719155
반응 노트
불러오는 중…