2-Chloro-5-nitroanisole → 2-Chloro-5-nitrophenol
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[O:11]C>Br.CC(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11]참가 물질
4
실험 절차
2-Chloro-5-nitroanisole (310 g, 1.7 mol) was taken up in a mixture of 48% HBr (1.5 L) and AcOH (1.2 L) and heated at reflux for 3 days. The dark solution was allowed to cool to room temperature, poured into ice water (10 L), and let stand for 3 h. The resultant dull yellow solid was filtered, washed with water, and dried in vacuo (230 g, 79%): mp 115–117° C.
후처리
- temperatureheated
- temperatureat reflux for 3 days
- filtrationThe resultant dull yellow solid was filtered
- washwashed with water
- customdried in vacuo (230 g, 79%)
출처 및 근거
- ORD 기록
- ord-9fdbebea0cd2417a98d35f38d61d0e08
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091204B2
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