Sodium Hydroxide → HCID 18387469, 화합물

HRID 863013노트

반응식

HRID 863013 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([N:9](C(=O)C1C=C(F)C=CC=1C)[C:10]1[N:15]=[CH:14][C:13]([C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=1)=[O:8].[OH-].[Na+]>CO.O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([NH:9][C:10]1[N:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22099733Methyl 6-[[bis(5-fluoro-2-methylbenzoyl)]amino]pyridine-3-carboxylate

생성물 1

HCID 18387469HCID 18387469, 화합물수율 81.2%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

A mixture of 12.0 g of methyl 6-[[bis(5-fluoro-2-methylbenzoyl)]amino]pyridine-3-carboxylate, 60 ml of methanol-tetrahydrofuran (1:1) and 23 ml of 5 N NaOH is stirred at room temperature for 16 hours. The mixture is concentrated under vacuum, diluted with 25 ml of water, cooled and acidified with 1N HCl. The mixture is filtered and the solid washed with water to give 6.3 g of the product as a white solid.

후처리

  1. concentrationThe mixture is concentrated under vacuum
  2. additiondiluted with 25 ml of water
  3. temperaturecooled
  4. filtrationThe mixture is filtered
  5. washthe solid washed with water

출처 및 근거

ORD 기록
ord-62b6898baa864e8dab762635617b313d
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719278

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