Methyl 4-[(biphenyl-2-carbonyl)-amino]-benzoate → 4-[(2-phenylbenzoyl)amino]benzoic Acid

HRID 863036노트

반응식

HRID 863036 반응식
[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1>C(O)C.[OH-].[Na+]>[C:1]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 1

HCID 7901139Methyl 4-[(biphenyl-2-carbonyl)-amino]-benzoate

생성물 1

HCID 105435024-[(2-phenylbenzoyl)amino]benzoic Acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A 3.15 g sample of methyl 4-[([1,1'-biphenyl]-2-carbonyl)amino]benzoate is refluxed for 8 hours in 100 ml of ethyl alcohol and 2.5 ml of 10N sodium hydroxide. The cooled reaction mixture is acidified with[[? acid]]and the desired product collected and dried to give 2.9 g of the desired product as a solid m.p. 246°-249° C. M+H=318.

후처리

  1. customThe cooled reaction mixture

출처 및 근거

ORD 기록
ord-3d4e8dd3196743c48caecdaf81f17ff4
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719278

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