Sodium borohydride → 5,6-Difluoro-1-hydroxyindane

HRID 863055노트

반응식

HRID 863055 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[C:7](=[O:12])[CH2:6][CH2:5]2.[BH4-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[CH:7]([OH:12])[CH2:6][CH2:5]2

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 117689445,6-Difluoro-1-indanone

생성물 1

HCID 196993185,6-Difluoro-1-hydroxyindane수율 99.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5,6-Difluoroindan-1-one (59.3 g, 0.353 mol) was dissolved in 1 L of ethanol and sodium borohydride (6.68 g, 0.176 mol) was added. The mixture was stirred for 48 hours and the ethanol was removed by evaporation under reduced pressure. The residue was partitioned between diethyl ether and water and the mixture was acidified with 1N hydrochloric acid. The mixture was dried over magnesium sulfate and filtered. The solvents were evaporated giving 5,6-difluoro-1-hydroxyindane (59.8 g) as an oil.

후처리

  1. customthe ethanol was removed by evaporation under reduced pressure
  2. customThe residue was partitioned between diethyl ether and water
  3. dry with materialThe mixture was dried over magnesium sulfate
  4. filtrationfiltered
  5. customThe solvents were evaporated

출처 및 근거

ORD 기록
ord-d56174c1718445edab3ca27d48ff8d9b
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719280

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