Dimethylformamide dimethyl acetal → N-Benzyloxycarbonyl-3(R,S)-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

HRID 863215노트

반응식

HRID 863215 반응식
[CH2:1]([O:8][C:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH:13]([C:21]([OH:23])=[O:22])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24]OC(OC)N(C)C>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH:13]([C:21]([O:23][CH3:24])=[O:22])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 196975891-[(Benzyloxy)carbonyl]-1,2,3,4-tetrahydroquinoline-3-carboxylic acid

생성물 1

HCID 19697580N-Benzyloxycarbonyl-3(R,S)-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1.87 g of N-benzyloxycarbonyl-1,2,3,4-tetrahydroquinoline-3(R,S)-carboxylic acid and 5 ml of N,N-dimethylformamide dimethyl acetal are heated at 80° C. in 20 ml of toluene for 4 h. The reaction mixture is concentrated and the residue is purified by means of FC (50 g of silica gel, mobile phase D): Rf (D)=0.29; MS: (M)+ =325.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by means of FC (50 g of silica gel, mobile phase D)

출처 및 근거

ORD 기록
ord-2b4870854d734d74a223ff95b621fcde
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719141

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