Methyl iodide → 3-Methoxyquinoline

HRID 863280

반응식

HRID 863280 반응식
[C:1](=O)([O-])[O-].[K+].[K+].CI.[OH:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2>CN(C)C=O.C(OCC)C>[CH3:1][O:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 113763-HydroxyquinolineHCID 11430Potassium Carbonate

생성물 1

HCID 5758073-Methoxyquinoline

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

1.05 g of anhydrous potassium carbonate and 0.48 ml of methyliodide are added to a solution of 1.0 g of 3-hydroxyquinoline in 8.5 ml of dimethylformamide and the reaction mixture is stirred at room temperature for 18 h. It is diluted with diethyl ether, the resulting suspension is filtered and the filtrate is concentrated. The crude product is purified by FC over 60 g of silica gel (mobile phase F) to give 3-methoxyquinoline: Rf (A)=0.53.

후처리

  1. filtrationthe resulting suspension is filtered
  2. concentrationthe filtrate is concentrated
  3. customThe crude product is purified by FC over 60 g of silica gel (mobile phase F)

출처 및 근거

ORD 기록
ord-8ee420d42c2148ab89a0b94ec8ce8b40
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719141

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