Methyl iodide → 3-Methoxyquinoline
반응식
[C:1](=O)([O-])[O-].[K+].[K+].CI.[OH:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2>CN(C)C=O.C(OCC)C>[CH3:1][O:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2참가 물질
6
실험 절차
1.05 g of anhydrous potassium carbonate and 0.48 ml of methyliodide are added to a solution of 1.0 g of 3-hydroxyquinoline in 8.5 ml of dimethylformamide and the reaction mixture is stirred at room temperature for 18 h. It is diluted with diethyl ether, the resulting suspension is filtered and the filtrate is concentrated. The crude product is purified by FC over 60 g of silica gel (mobile phase F) to give 3-methoxyquinoline: Rf (A)=0.53.
후처리
- filtrationthe resulting suspension is filtered
- concentrationthe filtrate is concentrated
- customThe crude product is purified by FC over 60 g of silica gel (mobile phase F)
출처 및 근거
- ORD 기록
- ord-8ee420d42c2148ab89a0b94ec8ce8b40
- 출처 데이터셋
- uspto-grants-1998_02
- 특허 번호
- US05719141
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