1,2-Dibromoethane → (2-Bromo-ethyl)-(3-fluorobenzyl)-amine

HRID 8636

반응식

HRID 8636 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[Br:10][CH2:11][CH2:12]Br.C(=O)([O-])[O-].[Na+].[Na+]>O>[Br:10][CH2:11][CH2:12][NH:6][CH2:5][C:4]1[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 78391,2-DibromoethaneHCID 10340Sodium CarbonateHCID 668533-Fluorobenzylamine

생성물 1

HCID 21983578(2-Bromo-ethyl)-(3-fluorobenzyl)-amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Combine 3-fluorobenzylamine (5.0 g, 0.0400 mol), fused sodium acetate (3.28 g, 0.0400 mol) and 1,2-dibromoethane (7.51 g, 0.0400 mol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,2-dibromoethane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound. The compound can form the hydrochloride salt.

후처리

  1. customRemove the unreacted 1,2-dibromoethane
  2. distillationby distillation
  3. extractionExtract the left-over residue with ether
  4. customevaporate

출처 및 근거

ORD 기록
ord-581af56aec3a433e9adb69447c08ffc7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091199B1

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