Hydrochloric Acid → Ceftiofur Hydrochloride

HRID 863649

반응식

HRID 863649 반응식
[ClH:1].[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1>O.CC(C)=O>[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1.[ClH:1]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 6328657Ceftiofur

생성물 1

HCID 9937686Ceftiofur Hydrochloride

시약·촉매·용매 1

HCID 18366337Propan-2-one--water (1/1)용매

실험 절차

The preparation of crystalline ceftiofur hydrochloride is considered to involve a typical crystallization. Several methods for the preparation of ceftiofur hydrochloride are described in U.S. Pat. No. 4,902,683. In one readily used method, once the hydrochloride salt is obtained by adding hydrochloric acid to a water/acetone solution of ceftiofur, the resulting solution is cooled slowly to obtain crystalline ceftiofur hydrochloride.

후처리

  1. temperaturethe resulting solution is cooled slowly

출처 및 근거

ORD 기록
ord-c8c261744d074e3ca4caa76f3e176479
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05721359

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