Sodium saccharin → N-[(4-Carbethoxybenzoyl)methyl]saccharin

HRID 864896

반응식

HRID 864896 반응식
Br[CH2:2][C:3]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][CH:6]=1)=[O:4].[CH:16]1[CH:21]=[C:20]2[C:22]([N-:24][S:25](=[O:27])(=[O:26])[C:19]2=[CH:18][CH:17]=1)=[O:23].[Na+]>CN(C)C=O>[C:9]([C:8]1[CH:14]=[CH:15][C:5]([C:3]([CH2:2][N:24]2[C:22](=[O:23])[C:20]3[C:19](=[CH:18][CH:17]=[CH:16][CH:21]=3)[S:25]2(=[O:27])=[O:26])=[O:4])=[CH:6][CH:7]=1)([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

4

반응물 2

HCID 656582Sodium saccharinHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

생성물 1

HCID 19417371N-[(4-Carbethoxybenzoyl)methyl]saccharin

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

45 mmol of ethyl 4-bromoacetylbenzoate in 120 ml of dimethylformamide and 48 mmol of sodium saccharinate are maintained at 100° C. for 180 minutes. After evaporation of the solvent, taking up in 200 ml of water, extraction with dichloromethane, drying and evaporation, the residue is taken up in isopropyl ether, then filtered and taken to the expected product.

후처리

  1. customAfter evaporation of the solvent
  2. extractionextraction with dichloromethane
  3. customdrying
  4. customevaporation
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-dcc26bda2edd4dff9ded4d69e88ab0cb
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565429

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