Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate → Ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

HRID 864913노트

반응식

HRID 864913 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-])=O)[CH:4]=[C:3]1[C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(O)C.[Pt]>[NH2:7][C:5]1[CH:4]=[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:2]([CH3:1])[CH:6]=1

참가 물질

4

반응물 1

HCID 10442704Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

생성물 1

HCID 11182847Ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

Ethyl 1-methyl-4-nitro-2-pyrrolecarboxylate (16.0 g, 0.081 mol) (M. J. Weiss, J. S. Webb and J. M. Smith, J. Amer. Chem. Soc., 79, 1266 (1957)) is dissolved in (200 mL) ethanol and (1.60 g) of 10% platinum on carbon is then added. The mixture is shaken for 16 hours in a PARR hydrogenator. The catalyst is removed by filtration through a pad of celite and the filtrate is concentrated in vacuo to a yellow oil. The oil is carried on directly without purification.

후처리

  1. customThe catalyst is removed by filtration through a pad of celite
  2. concentrationthe filtrate is concentrated in vacuo to a yellow oil
  3. customdirectly without purification

출처 및 근거

ORD 기록
ord-8c597d4cada74c72a970f25288991ca5
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565411

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