N-bromobutanimide → HCID 18941095, 화합물

HRID 865107

반응식

HRID 865107 반응식
[CH3:1][C:2]1[S:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:15][CH2:1][C:2]1[S:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 75892Naphtho[1,2-d]thiazole, 2-methyl-

생성물 1

HCID 18941095HCID 18941095, 화합물수율 63%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

To 3.98 g of 2-methylnaphtho[1,2-d]thiazole dissolved in carbon tetrachloride (40 ml) was added 3.56 g of N-bromosuccinimide and 0.20 g of benzoyl peroxide, followed by 6 hours of heating under reflux. After cooling the reaction solution, insoluble matter was removed by filtration, and the solvent was evaporated. The residue was subjected to silica gel column chromatography eluted with hexane-chloroform (5:1) to obtain 3.50 g (63%) of 2-bromomethylnaphtho[1,2-d]thiazole.

후처리

  1. temperatureof heating
  2. temperatureunder reflux
  3. temperatureAfter cooling the reaction solution, insoluble matter
  4. customwas removed by filtration
  5. customthe solvent was evaporated
  6. washeluted with hexane-chloroform (5:1)

출처 및 근거

ORD 기록
ord-13d380465b7a413fade7138bad7130a2
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565479

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