Water → HCID 19075284, 화합물

HRID 865158노트

반응식

HRID 865158 반응식
[CH2:1]([OH:7])[CH2:2]/[CH:3]=[CH:4]/[CH2:5][CH3:6].[H-].[Na+].Cl[C:11]1[C:15]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1.O>O1CCCC1>[CH2:1]([O:7][C:11]1[C:15]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1)[CH2:2]/[CH:3]=[CH:4]/[CH2:5][CH3:6]

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 5284503trans-3-Hexen-1-olHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

생성물 1

HCID 19075284HCID 19075284, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of trans-3-hexen-1-ol (900 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl) pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

후처리

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-913bfa756e4043bcb991fa1db1ae0b78
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565475

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