Ethyl Acetate → N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-6-yl]acetamide

HRID 865279

반응식

HRID 865279 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[OH:14])(=O)[CH3:2].[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24]Br)=[O:23])=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+].C(OC(=O)C)C>CN(C=O)C>[CH3:2][C:1]1[C:4]2[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=2[O:14][C:24]=1[C:22](=[O:23])[C:19]1[CH:20]=[CH:21][C:16]([CH3:15])=[CH:17][CH:18]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 692722-Bromo-4'-methylacetophenoneHCID 2775185N-(4-acetyl-3-hydroxyphenyl)acetamide

생성물 1

HCID 19959494N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-6-yl]acetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

0.72 g (3.75 mmol) of N-(4-acetyl-3-hydroxy-phenyl)acetamide and 0.81 g (4.1 mmol) of 2-bromo-4-methylacetophenone were dissolved in 5 ml DMF and 1,55 g (11.25 mmol) of potassium carbonate were added. The suspension was heated to 60° C. for 1 h and ethylacetate was added. The organic phase was washed three times with water, one time with a NaCl solution, dried over Na2SO4 and concentrated in vacuo. The residue was further purified by crystallisation (ethanol).

후처리

  1. washThe organic phase was washed three times with water, one time with a NaCl solution
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo
  4. customThe residue was further purified by crystallisation (ethanol)

출처 및 근거

ORD 기록
ord-d0515c7e03ac4eb4b21163d172c08022
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565488

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