Lincomycin Hydrochloride Anhydrous → Lincomycin trans-traumatate

참여 물질

반응 조건

반응 단계

2.28 g of trans-traumatic acid (10 mmol) are suspended in 100 ml of water cooled to 4° C. A solution of 8.86 g of lincomycin hydrochloride (20 mmol) in 100 ml water is eluted through a column cooled to 4° C. containing 35 ml of [OH--] Dowex 1×8 resin. The eluate free from chlorides is collected in the form of a suspension of traumatic acid kept under continuous stirring at 4° C. The resulting solution is frozen and lyophilized. The reaction yield is 10.1 g of dry product.

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